65 results
Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Vesicopustule on erythematous ... Discoid lupus erythematosus ... #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... tissue disease ... (SLE), Sjogren's ... ANA #patterns #rheumatology ... #diagnosis #differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... Congenital Diseases ... Systemic lupus erythematosus ... consumption • Vitamin B12 ... #Diagnosis #Hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... Treatment: • ... Systemic #Lupus #Erythematosus ... diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... - Neurological 12% ... involvement 3% SLE-Related ... Lupusreference #SLE ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... life-threatening • Treatment ... Evolution: Chronic disease ... lupus #Systemic #Erythematosus ... Management #Summary #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Splenomegaly - Differential ... • Gaucher's Disease ... Systemic Lupus Erythematosus ... Spleen #Enlarged #Differential ... Algorithm #Causes #Hematology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Systemic lupus erythematosus ... Systemic lupus erythematosus ... Systemic lupus erythematosus ... ANA #patterns #rheumatology ... #diagnosis #differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Lymphadenopathy - Differential ... Systemic Lupus Erythematosus ... Pancytopenia, WBC differential ... Algorithm #Causes #Hematology ... #Oncology