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management differential lupus syndrome algorithm ana dermatology erythematosus systemic workup classification vasculitis anemia patterns antibody joint pain testing thrombocytopenia arthritis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... in drug-induced SLE ... Antineutrophil #antibodies ... #diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Pleuritis) H Hematologic ... Arthritis R Renal Disease ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • B12 ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Differential Diagnosis ... - Anti-IF Antibodies ... - Anti-IF Antibodies ... #Hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Sensitivity of the ANA in Autoimmune & Nonrheumatic Disease #Diagnosis #Rheumatology #ANA #AntiNuclear #Antibodies #Sensitivity
& Nonrheumatic Disease ... #Diagnosis #Rheumatology ... #ANA #AntiNuclear ... #Antibodies #Sensitivity
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... • Specific for SLE ... Treatment: • ... #Summary #diagnosis ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis ... #rheumatology #
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Onset Still's Disease ... rheumatoid factor or antinuclear ... antibodies Exclusion ... Yamaguchi #Criteria #Diagnosis ... #Major #Minor #Rheumatology
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