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hematology management differential oncology syndrome disorders anemia aplastic comparison hemeonc leukemia pathophysiology acquired acutepe blood cancer cap cardiology cell chf
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... : • Malaise, bleeding ... #Leukemia #Hematology ... #Oncology #Diagnosis
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... Algorithm Features ... /bleeding, fatigue ... predominant immature cells ... #Algorithm #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #hematology #oncology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... glucocorticoid treatment ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis
Diagnostic Algorithm for Suspected Pulmonary Embolism Well's Criteria for PE • Clinical Signs and Symptoms of DVT
Diagnostic Algorithm ... for Suspected Pulmonary ... Embolism Well's ... PE • Clinical Signs ... and Symptoms of
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
Management Summary Diagnostic ... , signs, and complications ... transformation into AML ... • Treatment algorithms ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... and symptoms: ... neutropenia • Mucosal bleeding ... Symptomatic anemia Diagnosis ... #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
and Differential Diagnosis ... Algorithm Acute ... • Myloid (AML ... or λ), Smudge Cells ... #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... pattern of spread, B symptoms ... Responsive to Treatment ... #Diagnosis #NonHodgkin
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... WBC >100k, + lab signs ... Lysis of tumor cells ... Syndrome #TLS #diagnosis ... #management #hematology
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