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diagnosis algorithm causes management nutrition classification doac leukemia thrombocytosis anticoagulation aplastic ascites atlas b12 calculation chemotherapy chronic cll cyp3a4 folate
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... 80 fL) • Iron Deficiency ... 80-100 fL) • Bleeding ... Classification #Differential ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... telomeropathy Cancer ... #Diagnosis #Hematology
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... Hookworm infection, Bleeding ... #differential #
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Inflammation • Cancer ... • Early Iron Deficiency ... #Differential # ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... Liver diseases, Bleeding ... cells - G-6-PD deficiency ... key #diagnosis #differential ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Diagnosis #Algorithm #hematology
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
incidental DVT or PE in cancer ... thrombosis in cancer ... at high risk of bleeding ... Anticoagulation #Management #Hematology ... #Oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... infiltration (e.g. cancer ... , G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... , GATA2 deficiency ... , CTLA4 deficiency ... Treatment: ... #oncology #hematology
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