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diagnosis algorithm management causes oncology pancytopenia deficiency workup aplastic bruising cancer classification hasbled neutropenia risk thrombocytosis thromboembolism venous vte activation
Venous Thromboembolism Treatment Algorithm Branch points: Active bleeding? Active malignancy? Provoked? - Dr. Joseph Shatzel @Clotmaster #Management #VTE #DVT
Thromboembolism Treatment ... points: Active bleeding ... Thromboembolism #Treatment ... #Hematology #Anticoagulation
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... #Neutropenia #Differential ... Algorithm #Causes #Hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
validated for VTE treatment ... clinical benefit of anticoagulation ... of withholding anticoagulation ... #Calculators #Anticoagulation ... #Factors #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Features of hematologic ... B-symptoms, bruising/bleeding ... hepatomegaly • Labs: anemia ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... effect following treatment ... Iron deficiency anemia ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... neutropenia • Mucosal bleeding ... Treatment: • Consider ... diagnosis #management #treatment ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... 80-100 fL) • Bleeding ... Classification #Differential ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... #Pancytopenia #Differential ... #Diagnosis #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... - Acquired • Anticoagulation ... Coagulation #Bleeding ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Liver diseases, Bleeding ... key #diagnosis #differential ... #hematology
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