13 results
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... half-life = 40 days ([HCQI ... #Measurement #SLE ... #rheumatology # ... pharmacology #levels #lupus
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Associated - SLE ... • HCV, HBV Not ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... test, ANA (e.g., SLE ... or if a primary hematologic ... #Workup #hematology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... ANCA associated vasculitis ... (RA), Systemic lupus ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... • Infections: HCV ... (e.g. systemic lupus
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... inflammation, leading ... Erythematosus #SLE ... CNS #neurology #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... , and SLE) • Urinalysis ... • HIV • HBV HCV
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... 3) Limb oedema leading ... children (pediatric SLE ... #diagnosis #sle ... erythematosus #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... ANCA-Associated Vasculitis ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... other medications leading ... Hydroxychloroquine #hcq ... Risks #Benefits #Lupus ... #sideeffects #rheumatology