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diagnosis rheumatology differential sle algorithm erythematosus management apls approach arthritis cerebritis champs classification clues cns comparison complement cryofibrinogenemia cryoglobulinemia cryoglobulins
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... RA, Sjogren's), antiphospholipid ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... #differential #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Reactive: - Systemic ... Lupus Erythematosus ... Leukemia - History of Bleeding ... #Hematology #Oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... Positive in 60-80% of cases ... #Systemic #Erythematosus ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... autoantibodies that will cause ... inflammation, leading ... RheumOnePagers) #Systemic ... CNS #neurology #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... months to years) Systemic ... • Immunologic Workup ... comparison #table #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... 3) Limb oedema leading ... pericarditis » is...lupus ... #system #erythematosus ... #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... processes: • Systemic ... cryoglobulins • Negative causes ... HUS and HIT • Antiphospholipid ... #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
frequently affected systems ... : neuro, heme (bleeding ... Better call hematology ... you’ll do a good workup ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... • They can cause ... Cryoglobulins Cause ... lupus erythematosus
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... Hypercoagulable Workup ... maternal chromosomal causes ... excluded Testing: • Lupus ... Algorithm #diagnosis #hematology
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