395 results
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
Paget's Disease of Bone ... by an ↑ rate of bone ... mosaic" lamellar bone ... • Caused by ( ... pelvis, and long bones
Symptoms of Hypophosphatemia
 • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue
 • Hematologic:
Heart failure • Bones ... Growth retardation, Bone ... Phosphate #Symptoms #Signs
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... #Orthopedics #Causes
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... common than primary bone ... • Metastatic bone ... Signs/Symptoms:
Primary Bone Tumors - Differential Diagnosis Algorithm 

Metastatic - Most common tumour in adults
 - Breast
Primary Bone Tumors ... Differential Diagnosis Algorithm ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... #Orthopedics #Causes
Basilar Skull Fracture
Fracture through petrous portion of temporal bone 
 - Periorbital ecchymosis 
 - Hemotympanum
portion of temporal bone ... ecchymosis (Battle's sign ... Fracture #Battles #Signs
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Summary Clinical Signs ... hyperCalcemia 28% (bone ... • Anemia 78% (bone ... macrocytic • Bone ... clonal cell in bone
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
excessive bone ... turnover -> Incr bone ... Incr (abnormal) bone ... MSK • Deformed bones ... pathophysiology #diagnosis #signs
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... BrighamChiefs #Bone ... differential #diagnosis #causes
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Differential Diagnosis Algorithm ... Miscellaneous - Bone ... Hyperthyroid, Bony ... Differential #Diagnosis #Algorithm ... #causes #endocrinology