51 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
AIHA (48-70%) Cold ... HA (paroxysmal cold ... hemoglobinuria) • Cold ... Diagnosis #Table #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... Complement-Mediated • Cold ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Pathophysiology - Warm vs Cold ... Smear: spherocytes Cold ... Pathophysiology #diagnosis #hematology
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Immunosuppression, Splenectomy Cold ... BostonChiefs #Warm #Cold ... Hemolytic #Anemia #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
, C3d ( +/- ) Cold ... ) Paroxysmal cold ... Autoimmune #Hemolysis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... 3 Types of Cold ... Cold Agglutinins ... Primary Secondary Cold ... hemolytic #anemia #hematology
Acute Diarrhea - Differential Diagnostic Algorithm
Watery/Large Volume (Small Bowel)
 • Viral
 • Bacterial (e.g. C peffrjngens,
Differential Diagnostic Algorithm ... . cholerae, E. coli ... E. coli, C difficile ... Differential #Diagnosis #Algorithm
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Cold Urticaria Prevalence ... skin contact with cold ... minutes after the cold ... 10.1111/all.14674 #Cold ... Urticaria #diagnosis #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Autoimmune (AIHA)"Cold ... (e.g. primary cold ... differential #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... Differential #Diagnosis #Algorithm ... #workup #hematology