19 results
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... , C3d ( +/- ) Cold ... ) Paroxysmal cold ... #Autoimmune #Hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Differential Diagnosis Algorithm ... blood smear + DAT ... Heinz bodies, DAT ... idiopathic, malignancy, autoimmune ... Differential #Diagnosis #Algorithm
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... IgG mediated - DAT ... Smear: spherocytes Cold ... IgM mediated - DAT ... #Hemolytic #Anemia
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... AIHA (48-70%) Cold ... Mixed-type AIHA (7-8%) DAT-negative ... MatthewHoMD #Autoimmune ... #Hemolytic #Anemia
Hemolysis Classification - Intrinsic and Extrinsic Causes

Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... would be autoimmune ... already listed) and alloimmune ... #Classification ... Diagnosis #Causes #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... AIHA • Alloimmune ... Complement-Mediated • Cold ... Differential #Diagnosis #Algorithm
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... Positive Coombs testing ... post infectious setting ... CLL (older) • Autoimmune ... blood cells (RBCs) at
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... elliptocytosis, autoimmune ... Differential #Diagnosis #Algorithm ... workup #hematology #testing
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Autoimmune Hemolytic ... Non-Hodgkin Lymphoma Autoimmune ... alpha-methyldopa COLD ... #Hemolytic #Anemia ... #Differential #Algorithm
Pulmonary Hypertension Groups - WHO Classification
Group I - Vascular remodeling of pulmonary arteries
 • Idiopathic, HIV,
Hypertension Groups - WHO Classification ... hypoxemia • COPD ... Sarcoidosis, chronic hemolytic ... PH Functional Classification ... #Groups #WHO #Classification