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algorithm oncology thrombocytosis hemolytic morphology rbc workup acidosis agglutinin basophilia basophils bleeding bloodcell bruising cancer chronic cold elevatedmcv elevation erythematosus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... . lupus, CLL, lymphoma ... . sickle cell disease ... #Causes #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Malignant tumors, Acute ... #key #diagnosis ... #differential # ... hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
to Anemia - Differential ... Blood Loss ... • Acute Bleed - ... #Approach #Differential ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... malignancies • Anemia ... Myelodysplastic syndrome ... #Diagnosis #Causes ... #hematology #secondary
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... : Acute blood loss ... , deficiency anemia ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... extramedullary disease ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... Colitis and Crohn’s Disease ... #Diagnosis #causes ... #hematology #basophils
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) ... , Acute blood loss ... Myelodysplastic syndrome ... #diagnosis #causes ... #hematology
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