24 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
uremic syndrome ... . lupus, CLL, lymphoma ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... IgM associated lymphoma ... , Malignant lymphoma ... #Morphology #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... , Drugs, Liver Disease ... #Differential # ... Diagnosis #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Splenomegaly - Differential ... Malignant • Lymphoma ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... • Leukemia • Lymphoma ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
translocation • Types: Classification ... involvement Differential ... • Other hematologic ... oncology #diagnosis #differential ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... • Bleeding • Hemolysis ... (e.g. ... #Anemia #MCV #Classification ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Metastatic cancer, Lymphoma ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Myelodysplastic syndrome ... uremic syndrome ... key #diagnosis #differential ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... younger pts) Differential ... #hematology #diagnosis