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management differential rheumatology treatment oncology algorithm hepatology pathophysiology gastroenterology arthritis dermatology endocrinology hemeonc hemophagocytic hlh leukemia liver lymphohistiocytosis manifestations neurology
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Tunnel, Sicca Syndrome ... and ILD Complications ... Arthritis #RA #diagnosis ... #rheumatology # ... signs #symptoms
Kawasaki Disease (Mucocutaneous Lymph Node Syndrome) An rare systemic acute febrile vasculitic syndrome. Aetiology unknown. Affects
Kawasaki Disease ... Affects children ... lethal cardiac complications ... #Features #Signs ... #Symptoms #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... for workup, including ... anemia, Rebound effect ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Clinical Effects of Large and Small Pituitary Tumours Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Clinical Effects ... Tumours Local complications ... • Cushing's disease ... Pituitary #Tumors #Signs ... #Symptoms #Diagnosis
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
• CNS symptoms ... thin smear • Signs ... biopsy • Lab values ... supporting hematologic ... #diagnosis
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... mutations - Down syndrome ... / Symptoms / Complications ... pathophysiology #geriatrics #diagnosis ... #signs #symptoms
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
(AQP4-lgG disease ... pain • Extra-CNS complications ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... cells can indicate disease ... #workup #oncology ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
priapism • Lab values ... WBC >100k, + lab signs ... sudden death • Lab values ... #TLS #diagnosis ... #management #hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... skin thickening Signs ... and Symptoms: ... #diagnosis #signs ... #workup
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