29 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... : • Autoimmune ... Hemolytic Anemias ... Hemolytic Anemias ... Diagnosis #Algorithm #hematology
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Diagnostic Algorithm Autoimmune ... hemolytic anemia ... anemia Probable ... #hematology #diagnosis
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Hemolytic Anemia ... Hemolytic Anemia ... Hemolytic Anemia ... #Hemolytic #Anemia ... #comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... uremic syndrome (HUS ... idiopathic) - Autoimmune ... differential #diagnosis #hematology ... #anemia
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Microangiopathic hemolytic ... DIC, TTP, HUS) ... Microspherocytes: Autoimmune ... hemolytic anemia ... Smear #Analysis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... Hemolytic Anemia ... Warm #Antibody #Autoimmune ... #Hemolytic #Anemia ... management #treatment #rheumatology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
syndrome (ST-HUS ... known as atypical HUS ... anemia" • HELLP ... differential #diagnosis #hematology ... #hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... , aHUS, mechanical ... elliptocytosis, autoimmune ... #Anemia #Differential ... Algorithm #workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... → Sickle Cell anemia ... idiopathic, malignancy, autoimmune ... anemia (TTP, HUS ... #Anemia #Differential
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... MatthewHoMD #Autoimmune ... #Hemolytic #Anemia ... Diagnosis #Table #hematology