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differential hematology causes classification lupus rheumatology sle symptoms systemic aiha algorithm allergic allergy autoantibodies bruising cold definitions high hyperkalemia hypersensitivity
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs ... of anemia and hemolysis ... Hemolytic Anemias ... Hemolytic Anemias
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Hemolytic Anemia ... Hemolytic Anemia ... #Hemolytic #Anemia ... #comparison
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... Table Warm AIHA ... #Hemolytic #Anemia
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Systemic lupus erythematosus ... Antibody-mediated hemolysis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
surfaces • Ex: Autoimmune ... thrombocytopenia, Autoimmune ... Hemolytic anemia ... Systemic Lupus Erythematosus ... Classification #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Systemic #Lupus #Erythematosus ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
) Blood (75%): Anemia ... normochromic nomocytic or haemolytic ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
systemic lupus erythematosus ... ) - Alloimmune ... - Fanconi anaemia ... - Aplastic anaemia ... peds #pediatrics #diagnosis
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
leukocytosis, in vitro hemolysis ... ), sickle cell anemia ... amyloidosis, sickle cell anemia ... Autoimmune: Addison's ... #Differential #Diagnosis
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