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diagnosis hematology differential management oncology algorithm signs causes erythematosus lupus sle systemic aplastic chronic cll lymphocytic platelets agglutinin arteritis arthritis
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... Non-infectious (malignancy, rheumatologic ... Chronic Myeloid Leukemia ... BrighamChiefs #Thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Pathophysiology, Signs and Symptoms of Hemolytic Anemia #Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, Signs and Symptoms ... of Hemolytic Anemia ... Pathophysiology #Hemolytic ... #Anemia #hematology ... diagnosis #signs #symptoms
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... Iron deficiency anemia ... #Thrombocytosis ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Consider reactive thrombocytosis ... blood loss, Acute hemolysis ... , deficiency anemia ... Inflammatory Conditions: Rheumatologic
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
• Lymphoma • Leukemia ... vera, essential thrombocytosis ... Serum Sickness Hemolytic ... Algorithm #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... basophilia, and thrombocytosis ... ) CML Symptoms: ... - infiltrates (anemia ... #Hematology #Oncology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Cancer: • Leukemia ... Antibody-mediated hemolysis ... Differential #Diagnosis #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... • Symptomatic anemia ... to MDS or acute leukemia ... management #treatment #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
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