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erythematosus classification summary ana antibodies antibody antineutrophil antinuclear aortitis behcet cerebritis champs cns comparison cryoglobulinemia cryoglobulins diseases druginduced glomerulonephritis hypocomplementemia
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
lupus erythematosus ... in drug-induced SLE ... polyangiitis without renal ... + 30-60% • Renal-limited ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
causes differentiated ... Post-strep GN, Lupus ... #differential # ... diagnosis #algorithm ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... : Chronic disease ... #lupus #Systemic ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... & renal involvement ... Treatment: • ... diagnosis #rheumatology ... #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... Diagnosis: Systemic ... (Renal involvement ... differential #diagnosis ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
arteritis, Cogan's Syndrome ... Nodosa (PAN), ANCA ... lupus erythematosus ... (SLE), Sarcoidosis ... #Diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... (total 50, renal ... #differential # ... hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... APLA/LAC: • Renal ... #Systemic #Lupus ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months to years) Systemic ... : Chronic disease ... #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... , PRES Pathophysiology ... #rheumatology # ... #management #treatment
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