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differential rheumatology ana antinuclear algorithm associations autoantibodies diseases management monoclonal nuclear patterns table testing workup abnormal anca anemia antineutrophil antinxp2
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
(anti-nuclear antibody ... others (RNP, aPL antibodies ... Antiphospholipid Antibody ... Anti-cardiolipin (aCl ... #diagnosis #associations
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear Antibody ... Antineutrophil cytoplasmic antibodies ... scleroderma) - Anti-Scl ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
syndrome Anti-Scl ... disease Endomyseal antibody ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... anti-phospholipid antibodies ... changes), high MCV ... #Differential #Diagnosis ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... - Differential Diagnosis ... #Algorithm #Causes ... #Hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
/dL or CC < 40 ml ... Causes of false- ... amyloidosis Other causes ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
antiphospholipid antibodies ... FVIII antibody ... antiphospholipid antibodies ... #diagnosis #differential ... #hematology #coagulation
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
maternal chromosomal causes ... • Prothrombin Antibody ... • Cardiolipin Antibody ... Workup #Algorithm #diagnosis ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
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