106 results
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... Candida albicans ... , Candida krusei ... .2015.10.012 #Antifungal
Rare Invasive Yeasts - Species and Antifungal Therapy

Cryptococcus, 
Geotrichum, 
Kodamaea, 
(Pichia)ohmeri, 
Malassezia, 
Pseudozyma, 
Rhodotorula, 
Saccharomyces, 
Saprochaete
- Species and Antifungal ... Trichosporon, Candida ... Invasive #Yeasts #Antifungal
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
meningitis, severe candidal ... for non-severe candida ... #Flutycosine #Antifungal
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview

Mechanism: binds ergosterol in membrane and
Antifungal Polyenes ... 2nd-line for candida ... Overview #Polyenes #Antifungal
Tinea Versicolor (Pityriasis versicolor) 
NOT a dermatophyte infection 
Caused by saprophytic, lipid-dependent yeasts 
Clinical 
 •
Management • Topical antifungals ... • Oral antifungal
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... Cidal vs Candida ... choice for severe Candida ... Echinocandins #Antifungal
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
Tests Conduct antifungal ... Candidiasis #IC #antifungal ... diagnosis #management #candida
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Antifungal Coverage ... action of systemic antifungal ... species in which the antifungal ... PMC3146381/ #Antifungal
Common toxicities of antifungal agents. 
CNS = central nervous system; 5-FC = flucytosine; GI = gastrointestinal;
toxicities of antifungal ... #antifungal #toxicities
Candidemia Workup and Management - IDSA Guidelines
1) Antibiotics
 • Empiric: Echinocandins (e.g. micafungin) for most patients
ASAP • Other hardware ... Guidelines #Management #candida