466 results
diagnosis differential algorithm causes hematology anemia management pathophysiology clinical nephrology endocrinology workup signs symptoms classification treatment iron neurology hepatology disease
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Severe B12 deficiency ... • Mechanical hemolysis ... macroangiopathic hemolytic
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Defects • G6PD deficiency ... • PK deficiency ... Intravascular - Hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... G6PD deficiency)
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... ' nucleotidase deficiency ... , Hexokinase deficiency ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron deficiency ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Megaloblastic: Folate deficiency ... , B12 deficiency
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... spherocytosis, Hemolytic ... Thalassemia, Iron-deficiency ... cells - G-6-PD deficiency ... Schistocytes - Hemolytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Thalassemia, Iron deficiency ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron Deficiency
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Asplenism, Severe hemolytic ... Heinz Bodies: G6PD deficiency ... Sideroblastic anemia, Hemolytic
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