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hematology differential algorithm anemia management causes workup atlas chf chronic extravascular heartfailure hemolysis hfref intravascular laboratory leukemia lymphocytic morphology thrombocytosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... #differential #diagnosis ... #hematology #microscopy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Bleed • Hemolysis ... • Early Iron ... Deficiency # ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... • Microcytic - Iron-deficiency ... spherocytosis, Hemolytic ... , Thalassemia, Iron-deficiency ... Morphology #Atlas #key #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... G6PD deficiency) ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Sickle cell ... elliptocytosis - RBC ... • PK deficiency ... #Differential #Diagnosis
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Heinz Bodies: G6PD deficiency ... Thalassemia, Sickle cell ... #Bodies #diagnosis ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Consider sickle cell ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Differential #Diagnosis
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
turnover • Iron ... -12, or folate deficiency ... blood loss • Hemolytic ... Splenomegaly, Sickle Cell ... Increase #Decrease #Diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... inflammation) • Iron ... -100): • Non-hemolytic ... Spherocytosis, G6PD, PK, HbC ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... deficiencies: Iron ... deficiency (including ... anemia, Intrinsic RBC ... #differential #diagnosis
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