215 results
Rheumatoid arthritis (RA): X-ray features
 • Soft tissue swelling (best seen by comparing left & right
Narrowing • Bony ... the articular bone ... Peri-articular osteopenia (bones ... Radiology #Clinical #Pathophysiology
Paget's Disease of Bone

 • Characterized by an ↑ rate of bone turnover with both excessive
Paget's Disease of Bone ... by an ↑ rate of bone ... and formation of bone ... • Caused by ( ... more (polystotic) bones
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... #Orthopedics #Causes
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Differential Diagnosis Algorithm ... Miscellaneous - Bone ... Hyperthyroid, Bony ... Differential #Diagnosis #Algorithm ... #causes #endocrinology
Primary Bone Tumors - Differential Diagnosis Algorithm 

Metastatic - Most common tumour in adults
 - Breast
Primary Bone Tumors ... Differential Diagnosis Algorithm ... • Aneurysmal Bone ... Histiocytoma #Primary #Bone ... #Orthopedics #Causes
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
excessive bone ... turnover -> Incr bone ... Incr (abnormal) bone ... MSK • Deformed bones ... PagetsDisease #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... Secondary #Tertiary #pathophysiology
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... resorption in the bone ... resorption in the bone ... Hypercalcemia #Malignancy #Pathophysiology ... Differential #Diagnosis #algorithm
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Differential Diagnosis Algorithm ... production: • Bone ... suppression • Bone ... marrow failure • Bone ... Differential #Diagnosis #Algorithm