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Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
of solid-organ transplants ... Risk Factors by transplant ... • Solid organ transplant ... Type of organ transplanted ... symptoms, unexplained hematologic
Graft-Verus-Host Disease (GVHD) - Quick Reference Sheet Multisystem disorder that is a common complication of allogeneic hematopoietic
hematopoietic cell transplant ... when immune cells transplanted ... recognize the transplant ... disease in the transplant ... GVHD #CheatSheet #Transplant
Multiple Myeloma - Treatment Algorithm a) Newly Diagnosed Myeloma: Transplant Eligible b) Newly Diagnosed Myeloma: Transplant Ineligible doi: 10.1038/s41408-020-00359-2 #Multiple
Diagnosed Myeloma: Transplant ... Diagnosed Myeloma: Transplant ... Algorithm #management #hematology
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Transplant Infections ... Timeline Pre-transplant ... reactivation), HHV ... Protozoa: T. gondii #Transplant
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
• unicentric, HHV8 ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
Infections in Immunocompromised Patients - Differential Diagnosis Summary Innate Immunity: • Neutropenia • Phagocytic Deficiencies • Complement
• Solid Organ Transplant ... Allogeneic Stem Cell Transplant ... Deeksha Jandhyala @transplantID
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Consider stem cell transplant ... • If no transplant ... management #treatment #hematology
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... Light chain: - HHV8 ... de Fremont #HHV8
Clinical Manifestations of Human Herpes Viruses (HHV) Herpes simplex virus 1 HSV-1 Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV ... Herpes #Viruses #HHV
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Infiltration: • Hematologic ... and non-hematologic ... Algorithm #Causes #Hematology
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