16 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... common in SLE, autoimmune ... microsomal) - Autoimmune ... #diseases #diagnosis ... #table #rheumatology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Table Warm AIHA ... (48-70%) Cold AHA ... Cold Agglutinin Disease ... #Table #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
clinical associations ... Autoimmune diseases ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... , Others: SRP, Mi ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
Predisposing conditions: Autoimmune ... heart valves • MRI ... often seen • MRI ... - Infectious Diseases ... #table
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... subacute bacterial endocarditis ... Ann Marie Kumfer ... CHAMPS #Mnemonic #diagnosis
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... with auto-immune diseases ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... focal lesions on MRI ... autoimmune diseases ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
- Differential Diagnosis ... in 24h Airway disease ... Kaposi's sarcoma • Rheumatologic ... / Autoimmune: ANCA-Assoc ... regurgitation, Tricuspid endocarditis
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Anti-MDA5, anti-Mi ... exclusion Necrotizing Autoimmune ... Pattern: Proximal and ... #comparison #rheumatology ... #table