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diagnosis management autoantibodies comparison dermatology differential erythematosus sle systemic dermatomyositis syndrome activation adverseeffects antibodies antimda5 antimda5dm antinuclear antinxp2 antinxp2dm autoimmune
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SLE : systemic lupus ... ConnectiveTissueDiseases #ILD ... Differential #Comparison #Table ... #Pulmonary #Rheumatology ... #Associations
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... ANA (anti-nuclear ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Anti-dsDNA 60-80% Association ... with disease activity ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... Autoantibodies #Associations ... #diseases #diagnosis ... #table #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... Treatment: • Mild ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... CNS • Headache, mild ... antibodies • (-) ANA ... Erythematosus #Diagnosis #Rheumatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
of life Causes and ... clinical associations ... liquids The onset and ... Urticaria #diagnosis #rheumatology ... #comparison #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Prognosis: Usually mild ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Benefits in Lupus ... Benefits: ↓ Disease ... Prolonged QTc (association ... Risks #Benefits #Lupus ... #sideeffects #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... ILD worsens ... frequently described Association ... Dermatomyositis #rheumatology
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