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diagnosis differential management algorithm hypocalcemia workup secondary signs symptoms treatment 21hydroxylasedeficiency 21ohd acromegaly bulimianervosa complications cppd diabetes diabetic dka effects
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... )-alkali syndrome ... #Causes #differential ... #diagnosis #calcium ... #high #endocrinology
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus Calcium - Net Effect Hypercalcemia: ↑ intestinal
Parathyroid Hormone (PTH ... - Net Effect Hypercalcemia ... Parathyroid #Hormone #PTH ... #Phosphorus #pathophysiology ... #endocrinology
Hypercalcemia Workup and Differential Diagnosis Framework 1) Determine whether PTH-dependent 2) Assess for other hormonal causes 3) Assess for
Hypercalcemia Workup ... Determine whether PTH-dependent ... other hormonal causes ... Diagnosis #algorithm #endocrinology ... #calcium
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Algorithm Elevated PTH ... Low PTH: • Elevated ... Bony Mets - Calcium ... Diagnosis #Algorithm #causes ... #endocrinology
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Hypocalcemia - Diagnosis ... - Calcium Sequestration ... - DiGeorge Syndrome ... Signaling #Hypocalcemia ... Diagnosis #Management #endocrinology
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Tertiary Lab Comparison ... , ↑Calcium, ↑Vitamin ... , ↓→Calcium, ↓Vitamin ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate LOW PHOSPHATE - Low/NormaI PTH
Hypocalcemia - Differential ... Phenytoin, Nephrotic Syndrome ... Activating Mutation in Calcium ... Poisoning #Hypocalcemia ... Algorithm #Phosphate #endocrinology
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... 1) Clinical clues ... 2) PTH - Frankly ... differential #diagnosis #endocrinology ... #calcium #elevated
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... • Milk-alkali syndrome ... #Hypercalcemia ... #Causes #endocrinology
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS) Absolute Insulin deficit: - Type I DM:
Pathophysiology ... Hyperglycemic Hyperosmolar Syndrome ... - Type II DM pts ... #dka #hhs #pathophysiology ... #comparison #endocrinology
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