22 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Differential Diagnosis Neurologic-Centered ... DADS-M, Sporadic, late-onset ... Type I cryo GN, Light-chain ... deposition disease (light ... Differential #Diagnosis #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... ratio <8) light-chain ... #monoclonal #gammopathy ... algorithm #diagnosis #management ... #hematology #multiplemyeloma
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... constitutional symptoms ... amyloidosis • Rate ... #Significance #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... et diutinum Neurologic ... neuropathy) • Systemic late-onset ... • Crystalline: light ... Paraproteinemias #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Lysis Syndrome: • Pathophysiology ... proliferation rate ... TLS #diagnosis #management ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
→ fevers, night ... Constitutional symptoms ... fludarabine) 3) Monoclonal ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... Liver #Pregnancy #hepatology ... obgyn #diagnosis #management ... #pathophysiology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... ARDS to explain symptoms ... CKD, CHF, high rate ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... very high mitotic rate ... Classification #pathophysiology ... #Hematology #Diagnosis
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Complications of Monoclonal ... treatment of infective symptoms ... Renal disease - Monoclonal ... glomerulonephritis, light-chain ... Complications #diagnosis #hematology