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management differential oncology algorithm syndrome leukemia rheumatology aplastic causes chronic cll dermatology disease hemeonc hemolytic hemophagocytic hlh infectiousdiseases lymphocytic lymphohistiocytosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... if neutropenic fever ... #treatment #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Myelofibrosis Infectious ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... Supportive with treatment ... hepatomegaly and anemia ... Hepatobiliary #hepatology ... #differential #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... risk-stratification • Risks: infection ... only curative treatment ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... /fevers • Thrombocytopenia ... Treatment: ... #oncology #hematology ... #diagnosis #management
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... inclusions - If infection ... bartonella (oroya fever ... Algorithm #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... SLE) - Viral infections ... mountain spotted fever ... #hematology #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Symptoms: High fevers ... disease #hemolytic #anemia ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
) B symptoms → fevers ... 5) Symptoms of anemia ... Complications: 1) Infection ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
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