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rheumatology differential dermatology sle syndrome treatment erythematosus symptoms systemic oncology vasculitis arthritis blood classification clinical dermatomyositis hemophagocytic hepatology infections infectiousdiseases
Travel History - Clues to Infectious Disease Diagnosis in a Traveler • Where did you
Clues to Infectious ... Disease Diagnosis ... rural → Geographic disease ... → Leptospirosis ... Rabies, cat scratch fever
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... - Differential Diagnosis ... Malignancy: - Hematologic ... . autoimmune): Lupus ... #Differential #Diagnosis
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... Non-Infectious Causes ... • Leptospirosis ... Brucellosis Faget's Sign ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... • Autoimmune diseases ... Adult-onset Still disease ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... : HLH signs and ... following: • Fever ... #management #treatment ... #hematology
Biphasic Illness of Leptospirosis Some patients do not progress to severe disease. Others, rapidly develop severe disease
Biphasic Illness of Leptospirosis ... -14 days): • Fever ... rash • Others: nausea ... Biphasic #Phases #Diagnosis ... #Illness #Signs
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... autoantibodies #signs ... #differential #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... (RA), Systemic lupus ... , Sarcoidosis, HLA-B27 ... #Differential #Diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... • Periodic fever ... SJIA], systemic lupus ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Positive in 60-80% of cases ... Evolution: Chronic disease ... Erythematosus #Diagnosis ... #rheumatology
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