40 results
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
) Differential Diagnosis ... • Loose anagen syndrome ... - Secondary to Skin ... • Discoid lupus ... #causes
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Diagnosis Framework ... Capitis - Skin ... Disease: Discoid lupus ... : Lupus erythematosus ... , Loose anagen syndrome
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
areas -> Scaring alopecia ... hair follicles -> causes ... inflammation on skin ... pathophysiology #diagnosis ... #signs #symptoms
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Photosensitivity, Alopecia ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... constitutional symptoms ... Discontinuation of causal ... Photosensitivity, Alopecia ... #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... and permanent alopecia ... Differential Diagnosis ... • Nonscarring alopecia ... : • Symptoms limited
Focal / Localized Hair Loss (Alopecia) - Differential Diagnosis Algorithm

Scarring - Irreversible-biopsy required
 - Infectious
- Differential Diagnosis ... - Secondary to Skin ... • Discoid lupus ... Focal #Localized #dermatology ... #Algorithm #causes
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
symptoms by days ... Causes: - Idiopathic ... , breast CA - Hematologic ... - Lupus - Leukemia ... #diagnosis #dermatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Associated with skin ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... Sjögrens (15%) Skin ... Demyelinating syndromes ... erythematosus #signs #symptoms ... #diagnosis #rheumatology