61 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis ... Scleroderma) Multi-system ... LcSSc) - distal skin ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... anti-Sc170): Diffuse skin ... BCM_InternalMed #Systemic ... Autoantibodies #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Associated with skin ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology #
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... refractory disease Skin ... Neuro disease: • Systemic ... #pharmacology #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Arthralgia/arthritis, Skin ... Differential Diaqnoses ... solid cancers • Systemic ... #management #treatment ... #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Sjögrens (15%) Skin ... joints Nervous system ... signs #symptoms #diagnosis ... #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Hemolytic Anemia 1) DIAGNOSE ... FOR a cause → Systematic ... Hemolytic #Anemia #diagnosis ... #management #treatment ... #rheumatology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
bruising • Skin ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Ulcerative Blastomycosis Skin Lesion
57 asymptomatic M from Indiana nonpruritic, painless, progressive skin lesion lower back x
Blastomycosis Skin ... Denies any travel ... Diagnosis? ... Blastomycosis #SkinRash #dermatology ... #clinical #photo
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Diagnosis of IgA ... - Most common systemic ... - Systemic disease ... HenochSchonleinPurpura #HSP #Diagnosis ... #Rheumatology #