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differential management oncology algorithm dermatology rheumatology comparison hemeonc pruritus pulmonary secondary systemic thrombocytosis aplastic classification generalized lupus lymphocytic mds myelodysplastic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... microglobulin Treatment ... #Leukemia #diagnosis ... workup #oncology #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... myeloid leukemia ... (CML) - Dr. ... #Causes #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
and Differential Diagnosis ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... Blood #Disorders #hematology ... #Differential #Diagnosis
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... Myelofibrosis • Chronic ... Myeloid Leukemia ... #causes #Platelets ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... #hematology #hemeonc
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... (AML) • Chronic ... Anemia - Others ... Renal • Chronic ... endocrinology #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Diagnosis: • Pancytopenia ... Treatment: • Consider ... stem cell transplant ... to MDS or acute leukemia ... #treatment #hematology
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