38 results
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... Acute onset of skin ... >2 of: • skin ... Signs / Symptoms ... #Anaphylaxis #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... cold & mottled skin ... #21HydroxylaseDeficiency #21OHD ... #pathophysiology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... /Symptoms: - Fever ... - Vasculitic skin ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
Pathyophysiology ... diabetes Key signs ... /symptoms of HHS ... hypovolemia (dry MM, skin
Scarlet fever
• Delayed-type skin reactivity to pyrogenic exotoxin Requires prior exposure
• Diffuse erythematous eruption that generally
• Delayed-type skin ... diagnosis #clinical #photo ... #signs #symptoms
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
/ Symptoms: - ... Xeroderma (Dry skin ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Diagnosis and Management ... cases Clinical Signs ... years - May have signs ... /symptoms of active ... decreased reflexes Pathophysiology
Reactive Arthritis
 • Inflammation of joints (commonly large joints)
    - Asymmetric Oligoarthritis: Joint
Transient • Skin ... ReactiveArthritis #pathophysiology ... #diagnosis #signs ... #symptoms
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... tunnel, OSA, Incr skin ... endocrinology #pathophysiology
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
tightening of skin ... CREST #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms