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differential workup pancytopenia thrombocytosis causes management oncology cancer ckd classification hemodialysis hemolytic hodgkins leukocytosis lymphoma mds myelodysplasia myelodysplastic nephrology pruritus
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... #Algorithm #hematology ... #WBC #Leukemoid
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Platelet Count ... Reactive: • Anemia ... Non-infectious (malignancy ... Chronic Myeloid Leukemia ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... for workup, including ... hemolysis, deficiency anemia ... #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... Chronic Myelogenous Leukemia ... malignancy • ... Iron deficiency anemia
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Algorithm • 12 ... -13 g/dL, • ANC ... < 1800/uL, • platelet ... #Algorithm #hematology ... #workup
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... Algorithm Consumption ... Acquired Aplastic Anemia ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... and Differential Diagnosis ... Algorithm Consumption ... Acquired Aplastic Anemia ... #Algorithm #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... with or without platelet ... valve, vasculitis, malignant ... #Algorithm #workup ... #hematology #testing
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Hairy Cell Leukemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy ... Weight loss • Anemia ... Hodgkin Lymphoma Workup ... - Low Hb and platelets ... classification #hematology
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