60 results
Von Willebrand Disease - Clinical Presentation, Diagnosis and Management

- Dr. Eric Strong @DrEricStrong - Strong Medicine
Von Willebrand Disease ... VonWillebrand #Disease ... Diagnosis #Management #hematology ... #treatment
Treatments for Sickle Cell disease

#Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... Cell disease ... sicklecells #sickle #hematology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
and Associated Diseases ... Microscopy #Pathology #Hematology ... GrepMed Recommended Text ... Pathologic Basis of Disease
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Causes #Workup #Hematology ... GrepMed Recommended Text ... Hall Textbook of Medical
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
Cold agglutinin disease ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
cells: Sickle cell disease ... Alcohol abuse, Heavy metal ... Smear #Analysis #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
inhibitor • Liver disease ... • Underfilled test ... Thromboplastin #laboratory #hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... with more severe disease ... Used to monitor disease ... Treatment: • ... Summary #diagnosis #rheumatology