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differential management algorithm oncology anemia classification secondary systemic monoclonal nephrology thrombocytosis disorders encephalopathy lupus mgus pruritus sle syndromes table aplastic
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Myelogenous Leukemia ... effect following treatment ... #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
- Differential Diagnosis ... Myelofibrosis • Chronic ... Myeloid Leukemia ... #causes #Platelets ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential Diagnosis ... Myelodysplastic syndrome ... myeloid leukemia ... #Causes #hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... - Differential Diagnosis ... Myeloproliferative Disorder • Chronic ... #Algorithm #Causes ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Age > 50 • Chronic ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... transformation to acute leukemia ... #Management #treatment ... #hematology #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> AML: Blast crises ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic ... #Algorithm #hematology
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