17 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia ... #pathophysiology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... Risks factor for HIV ... plateletcount), peripheral blood ... smear, HIV/HCV ... ), (neurologic/psychiatric
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Dose-dependent tremor, ataxia ... dizziness, diplopia, ataxia ... Systemic effect -> Nausea ... #SideEffects #Pathophysiology ... #Psychiatry #Pharmacology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
dementia Pathophysiology ... integrity of the blood-brain ... penetrance through the blood-brain ... motor slowing and ataxia ... neurocognitive #disorder #dementia
Causes of Myoclonus - Differential Diagnosis
LOCALIZATION:
 • Cortical: Focal/multifocal: Distal UL+ Face, Action/sensitive induced
 • Sub-Cortical:
Causes of Myoclonus ... , HIV, Malaria, ... degenerations, dementias ... acid-base, opioids, psychiatric ... Differential #Diagnosis #Causes
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
of high parity blood ... donor • Pathophysiology ... : 2 hit mechanism ... without other cause ... transfusion • Pathophysiology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
often- Sensory ataxia ... Non-compressive Spinal Cord Causes ... - Viral: VZV, HSV ... , HIV, CMV, HTLV ... Blockage of the Blood
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Manifestations Causes ... increase venous blood ... Ophthalmoplegia - Ataxia ... vascular contraction, blood ... beriberi #nutrition #pathophysiology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Campylobacter jejuni - HIV ... Opthaloplegia • Ataxia
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... anemia • Sputum/Blood ... Carbapenems - IV ... #differential #causes