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diagnosis differential management rheumatology sle erythematosus manifestations syndrome systemic treatment vasculitis agammaglobulinemia algorithm alkaline alp als alzheimersdisease amyotrophic avascularnecrosis centralretinalartery
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Fits, Hemiplegia, Ataxia ... pain (20%) Renal disease ... Glomerulonephritis Myositis(5%) Blood ... erythematosus #signs ... #symptoms #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Erythematosus #SLE #CNS #neurology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
- Systemic Lupus ... syndrome (bulbar symptoms ... - opsoclonus-myoclonus ... Differential #Diagnosis #Causes ... #Neurology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... endothelium) & Decr blood ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... Sickle cell disease ... The underlying pathophysiology ... Crisis #Features #Signs ... #Symptoms
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... mainly AQP4-lgG disease ... disorders (Systemic lupus ... Manifestations #diagnosis #neurology ... #symptoms #signs
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Decr delivery of blood ... inflammation tends to cause ... interstitial lung disease ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
and signs below ... often- Sensory ataxia ... Non-compressive Spinal Cord Causes ... Blockage of the Blood ... Sarcoidosis, Behcet disease
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