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diagnosis differential management causes workup hematology criticalcare msk orthopedics endocrinology anemia hypercalcemia pathophysiology pulmonary treatment asthma dyspnea nephrology pancytopenia protocol
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... relationship between osteoblasts ... marrow cells and osteoblasts ... RANK stimulates osteoclast ... projections from an osteoclast
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts ... GrowthHormone #GH #FeedbackLoop
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... metastasized to the bone ... • Metastatic bone ... cells activate osteoblasts
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Reduced Bone ... Formation, Increased Bone
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Differential Diagnosis Algorithm ... Miscellaneous - Bone ... Hyperthyroid, Bony ... Differential #Diagnosis #Algorithm
Thrombocytopenia - Differential Diagnosis Algorithm Decreased production: • Bone marrow suppression • Bone marrow failure • Bone
Differential Diagnosis Algorithm ... production: • Bone ... suppression • Bone ... marrow failure • Bone ... Differential #Diagnosis #Algorithm
Pancytopenia - Differential Algorithm / Schema - Bone Marrow Failure - Bone Marrow Infiltration - Sequestration / Destruction #Pancytopenia #Differential
- Differential Algorithm ... / Schema - Bone ... Marrow Failure - Bone ... #Differential #Algorithm
Bone Lesion on X-Ray - Differential Diagnosis Algorithm Exostotic • Osteochondroma Asymptomatic &/or Non-Active Bone Scam •
Bone Lesion on X-Ray ... Differential Diagnosis Algorithm ... /or Non-Active Bone ... • Unicameral Bone ... Differential #Diagnosis #Algorithm
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
Primary Bone Tumors ... Differential Diagnosis Algorithm ... • Aneurysmal Bone ... #Bony #Tumors # ... Differential #Diagnosis #Algorithm
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