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diagnosis differential algorithm anemia coagulation management aptt bleeding bruising elevatedmcv erythrocytosis extravascular hemolysis macrocytosis prolonged pt treatment workup atlas basics
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Drug-induced AIHA - Abnormal ... PK deficiency Intravascular ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... Causes Intravascular ... (usually IgG) (e.g ... #Causes #differential ... #diagnosis #hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Increased PMNs • Polycythemia ... Heart Disease Abnormal ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... • Thrombus (e.g ... . polycythemia vera ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Destruction • Abnormal ... Rare • Drugs (e.g ... • Disseminated Intravascular ... #Hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Solid Tumour (e.g ... myelogenous leukemia • Polycythemia ... Diagnosis #Algorithm #Causes ... #Hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Erythrocytosis - Polycythemia ... - Acquired Causes ... Paraneoplastic (e.g ... ), TEMPI (VEGF normal ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... inflammatory disorders (e.g ... thrombocythemia (ET) • Polycythemia ... Differential #Diagnosis #Causes ... #hematology #secondary
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... exogenous, EPO levels: normal ... about secondary causes ... Algorithm #workup #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... macrosomia) • Bladder distension ... succenturiate lobe • Abnormal ... • Disseminated intravascular ... Diagnosis #Algorithm #Causes
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