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clinical diagnosis physicalexam differential neurology algorithm ophthalmology management msk sign syndrome cardiology orthopedics pulmonary ocular reflex pediatrics hemiballismus hepatology dermatology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Parathyroid gland ... adenoma • Parathyroid ... disease of bone Malignancy ... Hypercalcemia #Causes
Mechanism of malignancy-associated hypercalcemia. Abbreviations: 1,25(OH)2D, 1,25-dihydroxyvitamin D; NHL, non-Hodgkin lymphoma; PTH, parathyroid hormone; PTHrP, PTH-related
Mechanism of malignancy-associated ... lymphoma; PTH, parathyroid ... Hypercalcemia #Malignancy
Workup of Hypercalcemia - Differential Diagnosis Algorithm High or Normal PTH: • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Hyperparathyroidism: Parathyroid ... adenoma, Parathyroid ... hyperplasia, Parathyroid ... • High PTHrP: Malignancy ... nephrology #PTH #parathyroid
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... Parathyroid hormone–dependent ... hyperparathyroidism) Parathyroid ... Neoplasms - Parathyroid ... Hypercalcemia #Causes
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 Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
disease Renal Causes ... Hydronephrosis • Malignant ... Stricture • Malignancy ... Hematuria: • Malignancy ... Urolithiasis • Malignancy
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of Malignancy ... PTH-mediated • Parathyroid ... Hypercalcemia #Malignancy
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... • Burns Non malignant ... Non-hematologic malignancy ... Diagnosis #Algorithm #Causes
Radial Fracture Due to Parathyroid Carcinoma- ...A plain radiograph of the left arm showed a diaphyseal
Fracture Due to Parathyroid ... with an intact parathyroid ... found to have parathyroid ... which is a rare cause ... the patient’s parathyroid
Approach to determining the cause of a blood clot 1) Is it acquired? 2) Should you consider inheritable
determining the cause ... consider inheritable causes ... for undiagnosed malignancy ... VTE #diagnosis #causes
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... Most Common Causes ... Malignancy - 24% ... 1% Most Common Causes ... Hematologic Malignancy
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