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management differential oncology blood lymphadenopathy mds myelodysplastic product reactions apml cancer differentiation diffuse dyspnea eosinophilia essential et focal hemophagocytic hlh
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Infectious: • Acute ... effect following treatment ... #Algorithm #Causes ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential Diagnosis ... ): • Acute infection ... Myelodysplastic syndrome ... #Causes #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... Epitrochlear (Always pathologic ... Lymphadenopathy #LAD ... #Algorithm #Causes ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Fatigue • Acute ... Lymphadenopathy #LAD ... #Algorithm #Causes ... #Hematology #Oncology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... Heart failure - CAD ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... Deconditioning - Pain
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... transformation to acute ... #Management #treatment ... #hematology #oncology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - DRESS - AIN ... Mastocytosis - Acute ... Hypereosinophilic Syndrome ... #Causes #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - ACS, AKI, acute ... organ damage • Treatment ... #TLS #diagnosis ... #management #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... and lower jaw Treatment ... TNF blockers had ... #Rheumatology # ... #Dermatology
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