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Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Blood saves lives ... the deadliest complication ... of transfusions ... Transfusions are ... #Thresholds #Hematology
 End Stage Liver Disease (Cirrhosis) - Complications 
 • Ascites
 • Esophageal Varices
 • Hepatic
End Stage Liver ... (Cirrhosis) - Complications ... #Cirrhosis #Complications ... #diagnosis #management ... #summary #hepatology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... , Post transfusion ... - Thalassemia, Liver ... Renal diseases, Liver ... #differential #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Supportive care (transfusions ... neutropenic fever) Complications ... #diagnosis #management ... #treatment #hematology
Management and Complications of Cirrhosis and Ascites

Ascites Workup Algorithm
Ascites Management
Refractory Ascites
Hyponatremia
Spontaneous Bacterial Peritonitis (SBP)
Hepatic Hydrothorax
AKI in
Management and Complications ... Algorithm Ascites Management ... Cirrhosis #Ascites #Complications ... #gastroenterology ... #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatomegaly and anemia ... blood or exchange transfusion ... progressing to acute liver ... Liver transplant ... Hepatobiliary #hepatology
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... - Cirrhosis & complications ... Calling #Referral #Hepatology ... #Gastroenterology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... Monitor and Treat Complications ... #Pregnancy #hepatology ... obgyn #diagnosis #management ... #pathophysiology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... Extrinsic Causes: • Liver ... prosthetic valve • Transfusion ... #Hemolytic #Anemia ... classification #hematology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... differential #Diagnosis #Management ... #gastroenterology ... #algorithm #gastroenterology ... #hepatology