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diagnosis causes algorithm hyponatremia management rhabdomyolysis gitelman kidney treatment acute defects drugs epithelial hyperkalemia hyperreflexia hypomagnesemia hypomg hyporeflexia hypotonic inherited
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
- Differential ... • Tumor lysis syndrome ... Elimination: • AKI ... blockers - MCW Nephrology ... #Differential #
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #Hyponatremia #differential ... #diagnosis #table ... #sodium #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Hyponatremia - Differential ... Pain/Post-op • Neurologic ... Malignancy True hypovolemia ... • Reduced GFR, AKI ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Hyponatremia - Differential ... Pain/Post-op • Neurologic ... Malignancy True hypovolemia ... • Reduced GFR, AKI ... #Hyponatremia #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... ) - Differential ... Pre-Renal: • Hypovolemia ... Abdominal Compartment Syndrome ... #Diagnosis #nephrology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Pathophysiology ... #nephrology #diagnosis
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
associated with hypokalemia ... overdose) - Sodium ... renal Fanconi syndrome ... #Medications #differential ... #diagnosis #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia Focal Hyporeflexia: • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Guillain-Barré syndrome ... Hyperreflexia: • Hypocalcemia ... Testing #Causes #differential ... #diagnosis #table ... #neurology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... ratio 0.5%) Differential ... #diagnosis #nephrology ... #management #pathophysiology
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