9 results
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Cyanide Toxicity ... Amyl nitrite - causes ... #Cyanide #Toxicity ... #Toxicology #Pathophysiology ... #Management #Treatment
Naloxone for Clonidine Overdose
Indication: Altered mental status, CNS depression or respiratory depression due to clonidine overdose
Dosing:
Pediatrics: 10 mg ... strongly supported in pediatric ... cases. ... Clonidine #Overdose #toxicology ... #management
Naloxone - Toxicology

Adult starting dose:
 - 0.4 mg IV/IM/IO/SQ for non-opioid dependent patients
 - 0.04 mg
Naloxone - Toxicology ... opioid-dependent patients Pediatric ... search for other causes ... #Narcan #Toxicology ... #Management #Pharmacology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis ... #Management
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... no respiratory cause ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... #Toxicology #diagnosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
Abdominal pain, nausea ... deterioration Shock and metabolic ... - Anion gap metabolic ... #Toxicology #Diagnosis ... #Management #Ferrous
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Framework NCPE Pathophysiology ... Causes include: ... Opioid overdose • Naloxone ... • Salicylate toxicity ... differential #diagnosis #cardiology
Toxic Alcohol Ingestion: Methanol
Solvent found in cleaning and printing solutions, adhesives, stains, paint removers,
antifreeze agent in
1-2 mL/kg - Metabolite ... toxicity, but does ... NOT cause osmolal ... #Diagnosis #Management ... #Toxicology #Methanol
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Medication/Drug toxicity ... , Metabolic disturbance ... the underlying cause ... Syndrome #diagnosis #management