31 results
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic ... glomerular hematuria (RBC ... casts or dysmorphic ... RBCs in urine)? ... Comparison #Algorithm #Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... #Proteinuria #Nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
casts, dysmorphic ... → Refer to Nephrology ... for renal biopsy ... to Nephrology if ... cause not identified
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... edgarvlermamd - Nephrology ... Microscopy #Diagnosis #Nephrology
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... • RBC Casts - ... #Urine #Microscopy ... #nephrology #interpretation
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Malignancy True hypovolemia ... GI losses • Renal ... Cirrhosis • Nephrotic ... Hypo-osmolar urine ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Malignancy True hypovolemia ... GI losses • Renal ... Cirrhosis • Nephrotic ... Hypo-osmolar urine ... #Hyponatremia #Nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Hematuria - Differential ... hematuria • Signs ... casts → Diagnostic ... #urology #nephrology ... #renal #urine #
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
• White cell casts ... • Hyaline casts ... disease • Granular casts ... key #diagnosis #nephrology ... #casts
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
osmolarity If cause ... clinical context and signs ... Interstitial nephritis ... #Diagnosis #nephrology ... #causes