22 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Medications #Pharmacology ... #Pathophysiology ... Mechanisms #DOAC #Hematology
Mild Acne Treatment - Comedones (black/whiteheads), +/- few pustules 
1. Benzoyl Peroxide (BP) 
2. Topical Retinoid
Mild Acne Treatment ... few pustules 1. ... First line pharmacologic ... Management #Comedones #Pharmacology ... #Dermatology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
to be normal. 1: ... 1 Mix of Patient's ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
the critically ill ... coagulation defects. 1) ... Obstetrics #OBGyn #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
the critically ill ... coagulation defects. 1) ... AFLP #obstetrics #hematology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
the disease and ILD ... increases and ILD ... Phenotype 1 ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
cytometry — GP Ilb ... either severe Type 1 ... Platelet #disorders #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
cytokines, such as IL ... -1 and IL-6, leading ... Increased soluble IL ... Diagnosis #Management #Hematology ... #Rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Ischemic Liver, IBD ... Venous #Arterial #pathophysiology ... #hematology #differential