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management erythematosus systemic druginduced summary differential disease neurology syndrome table activation adult aosd associations autoantibodies calcium cerebritis classification cns comparison
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Prognosis: Usually mild ... constitutional symptoms • Treatment ... life-threatening • Treatment ... #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE ... CNS #neurology #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... nephritis, Class Ill ... Classification #Criteria ... #SLE #Systemic ... #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Age 20-40, F:M 9:1 ... life-threatening • Treatment ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease Treatment ... : • Mild disease ... #Summary #diagnosis ... #rheumatology #
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... #diagnosis #associations
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... pneumonitis • ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... erythematosus [SLE ... Histopathologic criteria ... Treatment: • Corticosteroids ... #Rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
- Yamaguchi criteria ... should be major: 1. ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... Autoimmune diseases: SLE ... #management #treatment ... #summary #rheumatology
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