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diagnosis differential management ana antinuclear dermatology antibodies associations autoantibodies cppd cytoplasmic diseases neurology patterns table testing anca antimda5 antimda5dm antineutrophil
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Seborrhea • Dermatomyositis ... Heliotrope • Dermatomyositis ... gangrenosum • IBD ... Antiphospholipid-antibody ... differential #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear Antibody ... erythematosus 1. ... Polymyositis and dermatomyositis ... 1. ... antibodies #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Drug-induced SLE Anti-Jo-1 ... Polymyositis / Dermatomyositis ... polyangiitis U1-RNP antibody ... disease Endomyseal antibody ... diagnosis #table #rheumatology
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... - Monoclonal antibody ... Basiliximab - IL ... Suppression of IL ... #Pharmacology #Pathophysiology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... (anti-nuclear antibody ... Antiphospholipid Antibody ... Myositis: Anti-JO-1, ... RNA Polymerase Ill
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
the disease and ILD ... increases and ILD ... prevalence of RP-ILD ... Phenotype 1 ... #rheumatology #
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
activity (e.g. antibody ... to be normal. 1: ... 1 Mix of Patient's ... #pathophysiology ... #hematology #laboratory
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... Antibodies: Anti-Jo-1, ... Demographics: - F:M, 2:1 ... dehydrogenase (LD ... PM #Diagnosis #Pathophysiology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
levels • NXP-2 antibody ... : • ILD was diagnosed ... Prednisone at 1 ... methylprednisolone 1 ... diagnosis #management #rheumatology
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