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hematology management algorithm syndrome causes table antinuclear comparison pathophysiology workup clinical joint oncology pain pancytopenia radiology testing abnormal aflp aptt
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... (anti-nuclear antibody ... Myositis: Anti-JO-1, ... Polymerase Ill ... #diagnosis #associations
On the left some diseases with a nodular pattern. 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary
with a nodular pattern ... . 1. ... Hypersensitivity pneumonitis ... #Clinical #Diagnosis ... NodularPattern #Differential
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... Inflammatory and ... hemoglobinuria • Antibody-mediated ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... Inflammatory Conditions: Rheumatologic ... Acute bacterial and ... #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... : The ANA patterns ... Patterns and Associated ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
activity (e.g. antibody ... to be normal. 1: ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... either severe Type 1 ... Platelet #disorders #hematology ... #diagnosis #Aggregometry
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
gangrenosum • IBD ... Antiphospholipid-antibody ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
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